Barcelona are one win away from defending their La Liga title after romping to a 5-0 derby success over Espanyol at Camp Nou , but will have Real Madrid hot on their heels after they overcame Valencia 3-2.
Luis Enrique's men ensured there would be no repeat of the 2007 'Tamudazo' derby, where a draw in the penultimate match of the season allowed Madrid to win that year's league under Fabio Capello.
A brilliant early free-kick from Lionel Messi sent Barca on their way, before Luis Suarez scored twice in the second half to make it 11 goals from his last four league appearances.
Substitute Rafinha Alcantara and Neymar wrapped up the victory with strikes in the closing stages as Barca eased to a fourth straight win, in which they have scored 21 goals without conceding.
A good day for Barca got even better as closest rivals Atletico Madrid suffered shock 2-1 loss at relegated Levante to crash out of the title race.
A brace from Cristiano Ronaldo helped Real Madrid to a 3-2 win over Valencia that ensures they go into the final day of the Liga season as Barcelona's only challengers for the title.
Ronaldo's 48th and 49th goals of another prolific season, which sandwiched a Karim Benzema strike, earned Zinedine Zidane's side an 11th-straight league win to keep them within a point of champions Barca.
Victory moves Madrid above neighbours and UEFA Champions League final opponents Atletico and means they visit Deportivo La Coruna next weekend knowing that a 12th win on the spin could see them overhaul Luis Enrique's team in the most dramatic of circumstances.
Madrid were comfortable for much of the game at the Santiago Bernabeu, with Valencia indebted to goalkeeper Diego Alves for restricting Ronaldo and co to three goals.
Atletico Madrid's La Liga title dream ended with a shock 2-1 loss at relegated Levante.
The result left Diego Simeone's men three points behind Barcelona, but Luis Enrique's side have a superior head-to-head record and cannot be caught by Atletico, while Real Madrid are now two points ahead of their cross-city rivals.
It was Fernando Torres who gave Atletico a stunning start with a goal after just two minutes, but the visitors were unable to push on at the Estadio Ciudad de Valencia.
Levante fought hard to give their fans a fine farewell in their last home game of the season and Victor Casadesus levelled the scoring just past the half-hour mark.
Stefan Savic and substitute Griezmann had chances to win it for the away side after the break, but Levante eventually emerged victorious as Rossi scored late on to seal a remarkable win.
Granada ensured their top-flight safety by inflicting a heavy 4-1 defeat on UEFA Europa League finalistsSevilla, Isaac Cuenca the hero with two goals and an assist.
Deportivo La Coruna also guaranteed they stay in La Liga by beating Champions League qualifiers Villarreal2-0, but Rayo Vallecano's safety hopes suffered a blow in a 2-1 loss to Real Sociedad.
However, fellow relegation battlers Getafe and Sporting Gijon - who are level on points - played out a 1-1 draw to keep Rayo in with a chance.
In other matches, Nolito scored the winner as Celta Vigo beat Malaga 1-0, Eibar and Real Betis played out a 1-1 draw, and Las Palmas versus Athletic Bilbao ended goalless in a game that saw veteran playmaker Juan Carlos Valeron bid farewell to his home crowd in Gran Canaria.
